Senator, author of the Warren Report, Anita Hill interrogator. He left the GOP in 2009 after voting for the stimulus but lost in the Democrat primary anyway. He was well-regarded in Pennsylvania. While his moderation was the ultimate thing that did him in, the perception in 2010 was that he had simply been around for too long.
Perhaps his biggest legacy will the so-called “Magic Bullet Theory”, the mis-understanding and mis-representation of which will feed JFK conspiracy theories long after we’ve all gone the same way.